The LAVAA volcano plot tool allows researchers to view not only the significance of PheWAS results of a variant, but also enables one to quickly see different directions and magnitudes of effect across phenotypes.
Additional attributes, such as the number of cases and if the variant is in a credible set for the phenotype, can also be visualized and output to a publication-ready file.
Begin by selecting a sample file from the FinnGen PheWeb from the Use sample data button on the right.
Alternatively, view the Documentation to create your own file and upload via the Upload new data button. FinnGen PheWeb variant files can be directly uploaded.
Brush through the data points by drawing a rectangle anywhere on the chart to see a table of details about the data.
You can reset the brush by clicking anywhere on the chart.
To clear the detailed data, press Clear selection.
You can highlight data points in a phenotypic category by hovering over the legend next to the chart.
For instance, you might want to see all the phenotypes relating to the legend represents the categories of data above the significance line.
FinnGen ICD-based categories are displayed but your own categories can be used also.
Inspect your own selection by drawing a rectangle anywhere on the chart and then pressing enter.
Mark interesting data points by clicking on them and move the label around by dragging it.
Remove individual labels by clicking on a close -button that appears on hover, or reset all labels by double-clicking a point.
Select dots in the chart.
✕